Hiring company: Merck
Job Description
Subject to applicable law, all prospective hires will be required to demonstrate that they have been fully vaccinated for COVID-19 or intend to be vaccinated for COVID-19 by November 1, 2021, or qualify for a medical or religious accommodation to this vaccination requirement. Hired candidates who are not vaccinated by November 1, 2021, and who have not been approved for a legally-required medical or religious accommodation will be subject to disciplinary action up to and including termination of employment, in accordance with applicable law
The Vaccine Drug Product Development in our Research & Development Division, West Point, PA is seeking a Senior Scientist or Engineer to join our department. The successful candidate will be expected to work as part of a team that is focused on the development of mRNA lipid nanoparticle (LNP) based vaccines. The main responsibilities include the design, execution, and documentation of experiments to evaluate the impact of formulation composition and the drug product manufacturing process on yield and stability of liquid and lyophilized products.
The successful candidate will be able to work in a fast-paced team environment, able to contribute to multiple programs, and be able to learn new skills quickly. The candidate should possess technical knowledge and experience related to development and characterization of lipid nanoparticle or mRNA-based drug product formulations. Additionally, candidate should have knowledge and/or experience related to parenteral formulation development, biochemical and biophysical characterization methodologies, particle size analysis, and lyophilization or other drying technologies. Good documentation practices, strong communication and collaborations skills are essential.
Education Requirements
Ph.D. +3 years, M.S. + 5 years, or BS + 8 years in chemical/biochemical engineering, chemistry, biochemistry or related discipline of related experience in process development
Experience and Skills
Required
Development and characterization of lipid and/or polymeric nanoparticle-based formulations
Strong understanding, knowledge and experience with drug product development and characterization of nucleic acid or lipid nanoparticle-based products
Understanding of liquid and lyophilized formulation development and the drug product manufacturing process
Preparation and manufacturing of safety assessment and clinical supplies
Principled, strong and effective written and verbal communication skills
Strong and effective organizational and technical problem-solving abilities
Ability to work in a fast-paced team environment
Preferred
Analytical characterization of mRNA or LNP-based products including particle size analysis, capillary electrophoresis, and other biochemical and biophysical methodologies
General knowledge and/or experience with synthesis of lipid nanoparticles
Drug product process development experience with a variety of large biological molecules and/or live virus vaccines for parenteral administration
General knowledge and/or experience with lyophilization, including techniques to examine residual moisture, the physical properties of lyophilized formulations, scale up and technical transfer considerations
Development/characterization of drug product manufacturing unit operations (freeze/thaw, mixing, sterile filtration, filling, stoppering, visual inspection, etc.)
Understanding of process related stresses that impact the quality and stability of vaccines
Manufacturing of clinical supplies
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Who we are …
We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.
What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.
NOTICE FOR INTERNAL APPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
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Employee Status:
RegularRelocation:
DomesticVISA Sponsorship:
NoTravel Requirements:
10%Flexible Work Arrangements:
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Number of Openings:
1