Hiring company: Merck
Job Description
New hires based in the US & Puerto Rico will be required to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption or accommodation to this vaccination requirement, subject to applicable law.
Our company is hiring! We are looking for a Senior Principal Scientist in Preclinical Development.
ADME and Discovery Toxicology within our company's Research Laboratories is seeking a dynamic and collaborative scientific leader of our Predictive and Translational Sciences group. This preclinically-focused team of scientists establishes mechanistic models to establish PKPD, mechanism of action and accelerate molecular design for early project teams in the Research Division portfolio. The team is focused on the design and execution of critical studies to inform modeling and translational for novel clinical candidates.
The successful candidate will collaborate closely with other research functions across the global company organization (including Preclinical Development, Translational Medicine, Protein Sciences, Chemistry, Biology, Pharmacology and Pharmaceutical Sciences) to innovate on new therapeutic opportunities. The lead of the team will actively partner with ADME Principal Investigators (PIs) to inform modality selection, to enable efficient optimization of candidates using in silico, in vitro and in vivo quantitative pharmacology approaches, and to contribute to a robust translational strategy. They will partner with other company leaders to assure the successful transition and progression of drug candidates from across modalities and therapeutic areas into the development pipeline. The incumbent will have the opportunity to contribute to our Research Division model informed drug development (MIDD) strategy. In addition, they will contribute to expanding our company's scientific network and reputation with academics and industry.
The incumbent will report into the head of the ADME and Discovery Toxicology in Preclinical Development. The successful candidate is expected to perform job duties independently with minimal supervision, and mentor others to develop similar capabilities, including:
Serving as a subject matter expert for model-informed approaches in drug discovery
Possess management and strategic mindset to position their team for success in delivering the portfolio, advancing staff careers, coaching, objective-setting and performance management
Ensuring development and execution of translational or mechanistic PK/PD, comparator, PBPK and other model-based analyses to inform program decisions and quantitative, predictive ADME capabilities
Mentoring and/or coaching ADME PIs to understand opportunities for model-informed program impact in the discovery space
This role is well suited for a skilled modeler and a quantitative pharmacologist, with a strong, integrated understanding of the elements of drug discovery and development, and ability to lead and make strategic decisions rapidly in a fast-paced discovery environment. Strong communication, collaboration and people management skills are required.
Required:
(a Ph.D. or equivalent degree with at least 10 years of experience) OR (an MS or equivalent degree with at least 14 years of experience), where “experience” means having a record of increasing responsibility and independence in a similar role in pharmaceutical drug development or academia.
Educational background in biopharmaceutics, pharmaceutical sciences, pharmacometrics, mathematics, statistics/biostatistics, computational biology/chemistry, chemical/biomedical engineering, or a related field.
An exemplary record of increasing responsibility, independence, and demonstrated impact in driving drug discovery decisions through application of model-based approaches with a focus on protein therapeutics and PK/PD modeling.
Demonstrated experience in supervising, coaching and mentoring more junior scientists.
Preferred:
Proficiency in NONMEM, Phoenix, Matlab, R-Project or other similar software.
Demonstrated impact integrating ADME, PK/PD and modeling to guide molecule design and lead candidate selection to generate decisive data to advance the pipeline.
Strong publication record and reputation in the external scientific community.
Proficiency in written and verbal communication, interdisciplinary collaboration and problem scoping and planning.
Demonstrated ability to participate in and to lead an interdisciplinary team and to guide and collaborate with other scientists.
Formal people management experience.
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Who we are …
We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.
What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization.
NOTICE FOR INTERNAL APPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
Residents of Colorado
Click here to request this role’s pay range.
Current Employees apply HERE
Current Contingent Workers apply HERE
US and Puerto Rico Residents Only:
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
For more information about personal rights under Equal Employment Opportunity, visit:
Pay Transparency Nondiscrimination
We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.
Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status:
RegularRelocation:
DomesticVISA Sponsorship:
YesTravel Requirements:
10%Flexible Work Arrangements:
Shift:
Valid Driving License:
Hazardous Material(s):
Number of Openings:
1